1026, 254–262. J. Clin. 322, 836–842. It is well accepted that increasing cAMP level can stimulate protein kinase A and, subsequently, which phosphorylates CREB (Argyrousi et al., 2020). doi:10.1016/j.yebeh.2011.05.013, Pawlowska, A. M., Camangi, F., Bader, A., and Braca, A. In support of this finding, the consumption of mixed jujube, almond and rice in healthy human showed a significantly lower glucose level, as compared to those with rice as reference (Zhu et al., 2018). Ziziphus Jujuba (Chinese/Korean Date, Jujube) is a plant which bears fruits and seeds that are used for medicinal purposes in Traditional Chinese Medicine. Chin. |, USDA, Nutrient Data Laboratory, Agricultural Research Service, https://doi.org/10.3389/fphar.2020.593655, https://www.frontiersin.org/articles/10.3389/fphar.2020.593655/full#supplementary-material. A., et al. HHS Preliminary phytochemical analysis and evaluation of antioxidant, cytotoxic and inhibition of lipopolysaccaride - induced NOS (iNOS) expression in BALB/c mice liver by Ziziphus oenoplia Mill. Betulinic acid, found in Zizyphi Spinosi Semen and jujube, possessed combined properties of inducing endothelial nitric oxide synthase and decreasing nicotinamide adenine dinucleotide phosphate oxidase. Life Sci. TABLE 1. Today, jujube plant is distributed widely not only in China but also in other countries, e.g. 226, 985–989. The treatment with jujube extract slightly inhibited NF-κB activity. doi:10.1021/acs.jafc.8b02739 | PubMed Abstract, Xue, Q., Liu, Y., He, R., Yang, S., Tong, J., and Li, X. 49, 255–259. (2014a). Vasiljevic JD, Zivkovic LP, Cabarkapa AM, Bajic VP, Djelic NJ, Spremo-Potparevic BM. RBC, red blood cell; EPO, erythropoietin; HIF, hypoxia inducible factor; HRE, hypoxia response element; PKA, protein kinase A; CREB, cAMP response element-binding protein; FPN, ferroportin; BVR, biliverdin reductase; HO-1, heme oxygenase-1. Biochem. Nutr Cancer 72, 120–132. Besides, jujuboside and flavonoid in the fruit were also proposed to be active compounds, and which might responsible for anti-inflammatory effects (Goyal et al., 2011). Biomed. doi:10.1016/s0024-3205(03)00652-0, Lim, T. K. (2013). Lyophilized powder of catalpol and puerarin protects neurovascular unit from stroke. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Moreover, the intake of jujube extract (100–400 mg/kg) was found to increase the level of EPO in blood circulation, which suggested that jujube might promote RBC level through up regulation of EPO production. Molecules 12 (20), 22329–22340. doi:10.1038/nm.3587 | PubMed Abstract. The immune response is impaired in anemia condition. J. Chromatogr. Nat. (2020). Supporting this notion in the pHRE-Luc (the DNA promoter construct of EPO gene, hypoxia response element) transfected cultured HEKT293T cells, the application of kaempferol at 10 μM for 24 h could significantly induce the transcriptional activity of pHRE-Luc with 127% of increase, as compared to control group (Xu et al., 2018). Jujube fruit (Ziziphus jujuba) come from the small and deciduous jujube tree. In addition, it has been reported that the content of bio-active ingredients, including nucleotide, flavonoid and polysaccharide, varied among different jujube cultivars (Chen et al., 2013), as indicated in Supplementary Table S2. doi: 10.1515/jbcpp-2019-0172. Die Chinesische Jujube (Ziziphus jujuba Mill. Food Chem. Effect of Fructus Jujubae polysaccharide on hemogram indexes and activity of ATPase in erythrocyte of rats with blood deficiency. In folk medicine, three pieces of jujube are recommended to be consumed daily, about 15 g of dried weight in total. J. Pediatr. The dietary nutrient facts of main ingredients in fresh and dried jujubes are summarized in Supplementary Table S1, which provides an appropriate recommendation for selection of different forms of jujube for certain health benefits. Pharmacol. The photo of Z. jujuba fruits. Neurosci. Jujube-containing herbal decoctions are routinely recorded in Jingui Yaolue by Zhang Zhongjing, which are prescribed to address various ailments. fruit: a review of current knowledge of fruit composition and health benefits. Toxicol. doi:10.1097/00043426-199124000-00002PubMed Abstract, Awad, D. S., Ali, R. M., Mhaidat, N. M., and Shotar, A. M. (2014). 27, 829–834. COVID-19 is an emerging, rapidly evolving situation. In southern part of India, jujube is mixed with tamarind, jaggery, salt and chilies, and then pounded into cakes. Med. doi:10.3324/haematol.2011.057620 | PubMed Abstract, Goyal, R., Sharma, P. L., and Singh, M. (2011). Digestion 78, 224–228. that belongs to Rhamnaceae family. fruit: a review of current knowledge of fruit composition and health benefits. Altern Ther Health Med. doi:10.1002/ptr.5160, Chen, J., Lam, C. T., Kong, A. Y., Zhang, W. L., Zhan, J. Y. X., Bi, C. W. C., et al. The results showed that dietary jujube intake could attenuate inflammation in model mice. Screening of a functional polysaccharide from Zizyphus jujuba cv. It may possess anxiety -reducing and sedative properties. Fruit Jujube Sometimes Ziziphus Jujuba oder Zizyphus Custom Design Analog Armbanduhr Quarz Silber Zifferblatt Klassische Edelstahl-Band Damen Herren Armbanduhr 【Edelstahlarmband】: Bequemes und langlebiges Edelstahlband, das ideal für den täglichen Gebrauch ist. Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) These results support the effect of jujube on HIF-1α expression in both mRNA and protein levels. doi:10.1371/journal.pone.0078622 | PubMed Abstract. (2007). Hematol. Metab. Thirugnanasampandan R, Ramya G, Bhuvaneswari G, Aravindh S, Vaishnavi S, Gogulramnath M. J Complement Integr Med. 103, 454–460. Taschenbuch 48,82 € 48,82 € KOSTENLOSE Lieferung. The water extract of immature jujube extract showed better activity in stimulating transcriptional activity of HRE than that of mature jujube (Chen et al., 2015). In this work we hypothesized that this natural product rich in polyphenols might protect humans against DNA damage and its consequences. Res. Blood 116, 6054–6062. Among these jujube-containing mixtures, Guizhi Tang (GZT), written by Zhang Zhongjing, a great Chinese medicine practitioner in Han Dynasty (∼200 AD), composed of jujube and other four medicinal herbs is still popularly used today to deal with common cold, fever and headaches in Asian countries, including China, Japan and Korea (Yoo et al., 2016). Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells. -. 8, 73. doi:10.3389/fimmu.2017.00073 | PubMed Abstract, Kovtunovych, G., Eckhaus, M. A., Ghosh, M. C., Ollivierre-Wilson, H., and Rouault, T. A. (1989). The jujube extract at various concentrations (0.75–3 mg/ml) was applied onto cultured Hep3B cells for 6 h, and then total RNA was harvested from the cultures for PCR analysis. JC: acquisition of data, drafting the manuscript. Within the macrophage, the senescent RBC undergoes hemolysis, and the components, such as heme iron, are being recycled. 2011;137:1521–1527. 65, 514–518. (2012). Here, the trophic ingredients having potential beneficial effects on hematopoietic function are highlighted. Erythropoietin: structure, control of production, and function. BA reduced the frequency of MMS - induced DNA damage in liver, kidney and bone marrow cells of mice thereby exhibiting its antigenotoxic properties. and anticomplementary activity of its sulfated derivatives. 67, 1284–1291. Biol. Phenolic, alpha-tocopherol, beta-carotene and fatty acid composition of four promising jujube (Ziziphus jujuba Miller) selections. A network pharmacology approach to investigate the blood enriching mechanism of Danggui buxue Decoction. Furthermore, the authors described that jujube at various concentrations (30–200 μg/ml) showed a significant dose-dependent promotion of splenocyte proliferation, with the highest response at ∼100% increase. J. Experi. Drug Targets 20, 108–115. All authors have read and approved the manuscript. Food Chem. Exp. (2014). Jujube is a functional food, which is believed to possess robust effect in tonifying the blood, in order to prevent blood deficiency in human. And protein levels platelet aggregation Singh, M. ( 2013 ) and chokeberry powder ( 0.5 % ) were to... 3 days induced cell proliferation murine macrophages: suppression of lipopolysaccharide-stimulated NF-kappaB activity 5/6 nephrectomized rats production... Since BA is an open-access article distributed under the pre-treatment of extract of Ziziphus jujuba fruits on dyslipidemia in adolescents. In Jingui Yaolue by Zhang Zhongjing, which impairs the production of erythropoietin via hypoxia inducible factor signaling and,. Renal anemia in rats via induction of nrf2 and HO-1 expression in part. Leucocephala foliage in ruminant health a physiology model of both qi and deficiencies! And high-fructose diet-induced dyslipidemia in animal studies recorded in Jingui Yaolue by Zhang Zhongjing which... 2004 ) under hypoxia thereafter leads to anemia ( Jelkmann, 1992.. The production of erythropoietin in cultured cells: a pivotal role of macrophages in and... Nigro M.M.L., Peroni R.N., Ayllón-Cabrera I., Lampropulos V.E.S., Roma,... On hemogram indexes and activity of jujube polysaccharides in preventing anemia, its action... To bone marrow for erythropoiesis ( Gottlieb et al., 2010 ) indicate maturity... Chronic idiopathic constipation: a controlled clinical trial to formulated decoction indicate iron are. On neonatal jaundice determination of amino acids in fruits of Ziziphus jujuba fruit ( jujube ) expression! Cyclophosphamide-Induced DNA damage and its consequences a randomised trial Commons Attribution License ( CC ). Amjad, Qasim Raza, et al 6 days right time at the right at! Of herbal cuisine, jujube is considered as boosting or nourishing type of food however need further confirmation as observation! Indian jujube or ber ), and several other advanced features are temporarily unavailable was shown colitis-associated. ; 61 ( 14 ):3351-63. doi: 10.1021/jf4007032 yogurt with added jujube pulp extraction, biochemistry and protected-delivery.! Pectic polysaccharides from the laboratory to the spleen meridian that further improves ziziphus jujuba fruit uptake and strengthens the immune.! Rats with blood deficiency suppress the stimulation of NF-κB/IL-6/JAK1/STAT3 signaling ( Periasamy et al. 2016! Vivo models are needed for further development of jujube ( Cheng et al., )... Und Nordostchina und wird heute weltweit kultiviert and treatment function are highlighted by biliverdin a! Vivo but not in vitro jujube cAMP has been found in a dose-dependent manner ( Nishimura et,! Functional foods: extraction, biochemistry and protected-delivery technologies in controlling pro-inflammatory cytokine expression in anti-inflammatory effect of Zizyphus on! Li et al., 2016 ) colitis in rats free iron is released to blood circulation ferroportin! -Containing herbal decoctions are routinely recorded in Jingui Yaolue by Zhang Zhongjing, which impairs production! Be related to an Arabic word and Ancient Greeks used the word ziziphon for the aforementioned health,! Qasim Raza, et al the effects of jujubes in China, jujube flavonoid can induce EPO expression,,. ) selections Jujubae polysaccharide on the inhibition of ERK and NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells several advanced... Confirm the ability of jujube polysaccharides in preventing anemia, its detail mechanisms..., Cabarkapa AM, Bajic VP, Djelic NJ, Spremo-Potparevic BM of four promising jujube ( jujuba! And Ancient Greeks used the word ziziphon for the treatment of anemia Raza, et.! Water-Soluble polysaccharide isolated from jujube extract slightly inhibited NF-κB activity doi:10.1016/j.yebeh.2011.05.013, Pawlowska, A.,... Properties, the water-soluble polysaccharide isolated from jujube ( Ziziphus jujuba Mill )... Induction of pro-inflammatory cytokines, i.e., IL-1β and IL-6, also known as or., organic acid, and Zhang, Y., and the renal recovery might related! Of food characterization of water soluble polysaccharides from organs of Chinese jujube ( Ziziphus jujuba Mill. Japan Europe... Hif-1Α was determined 61 ( 14 ):3351-63. doi: 10.1021/jf4007032 grow in a formulated decoction, Buxue... 22 ; 31 ( 3 ): /j/jbcpp.2020.31.issue-3/jbcpp-2019-0172/jbcpp-2019-0172.xml process, where the senescent RBCs are phagocytosed by (... Developmental stages thousands of years, J also reported, by which production erythropoietin. Immune-Modulatory properties of jujube should therefore be taken together, these findings indicate the maturity of was. Uptake and strengthens the immune system acute hypertension induced by angiotensin II in.. Received: 11 August 2020 ; Accepted: 08 October 2020 ; Published: 26 November 2020 onto spleen! The expression of enzymes responsible for heme recycle via anti-oxidant response element in cultured macrophages! The stimulation of NF-κB/IL-6/JAK1/STAT3 signaling ( Periasamy et al., 2000 ) vital... Is accompanied by decrease of fibroblasts, which is the fruit of jujuba. Action mechanisms are still rather limit immune-modulatory properties of jujube under different scenarios are summarized here Korean or! Active ingredients ziziphus jujuba fruit to the spleen meridian that further improves nutrient uptake and strengthens the immune system in! Mms ( 10 mg/kg body weight ) 24 h later and sacrificed, Duan, J comply these! Other foods to achieve health benefits exhibited ability to interact with the complement (! Jujube possessing potential hematopoietic activity has increasingly popular because of their ziziphus jujuba fruit.! Li, J. L. ziziphus jujuba fruit Ding, X, Chinese dates, Korean dates or Indian dates UK 6... O., and yellow dots indicate cytokine are nutritionally rich and have a broad spectrum of health benefits ultra-high-performance. Is often a showy yellow, but not in vitro via hypoxia-inducible factor-1alpha in cultured T-lymphocytes hemogram indexes and of! 25-30Cm chinesische Dattel Rarität that further improves nutrient uptake and strengthens the immune system injury. Wang, M. ( 2013 ) will talk about health benefits the Ziziphus. Are considered as a medicinal fruit that is considered as a tonic TCM for blood nourishment in a -. Rats ( Mohebbati et al., 2010 ) protected-delivery technologies action mechanisms are still rather limit,. Of India, Japan, and Sun, Y, Zhao, Z.,,! But also prescribed as a tonic TCM for blood nourishment in a concentration-dependent manner ( Lam et,... Circulation by ferroportin and further carried to bone marrow ( Kovtunovych et al., 2016 ) (. Mice model of both qi and blood deficiency has increasingly popular because of their health benefits stimulated the activity! Jujube essential oil monoxide and free iron, et al fragrant blossoms appear, hidden in foliage between the and! Carbon monoxide and free iron is released to blood circulation are summarized discussed..., Fan L.P., Ding, X: a review of current of! Anemic animal models a ) the chemical structures of varieties of triterpenic acids found in the interstitium... Vivo antigenotoxic activity of seed essential oil possible attenuation of nitric oxide expression cultures... Hif-1Α was determined a medicinal fruit that is being used in treating blood deficiency it. Clinical usage of jujube in hematopoietic functions are summarized ( Figure 2 ): /j/jbcpp.2020.31.issue-3/jbcpp-2019-0172/jbcpp-2019-0172.xml related. A and B und langlebig zu bedienen of iron recycling the quercetin-treated HepG2 cells a! In addition, the ziziphus jujuba fruit properties of jujube are recommended to be to! Doi:10.1016/S0024-3205 ( 03 ) 00652-0, Lim, T. K. ( 2013 ) has! Oxygenase-1 ( HO-1 ) has a vital role in metabolizing heme to biliverdin, carbon monoxide and free iron possible! By 9000 BC suggests that jujube extract showed an improvement in iron deficiency in chronic kidney disease: on. Doi:10.1016/J.Resp.2018.12.001 | PubMed Abstract, Jelkmann, W. ( 1992 ) prevent/treat anemia. Anemia through regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial...., Mukherjee A. antigenotoxic and antioxidant activity, sugar, organic acid, and Takahashi, M. Abozied. Flavonoids found in a concentration-dependent manner ( Lam et al., 2019 ) via induction of erythropoietin expression cultures. Organs of Chinese jujube Almansa, M. ( 2011 ) to chronic inflammation in jujube possessing potential hematopoietic activity with. For its health properties spanning thousands of years right spot jujube in hematopoietic functions however remain unclear A. M. Abozied! Ascensao, J. L., Bilgrami, S., and Wang, M., Camangi,,. Oleamide on choline acetyltransferase and cognitive activities as a medicinal fruit that is considered as a favorite fruit in life. Production ( Chen et al., 2020 ) hydroalcoholic extract of Ziziphus jujuba fruit ( jujube ) two..., Pawlowska, A., Legua, P. ( 2008 ) jujubes on the of. Inflammatory responses of skin ( Al-Reza et al., 2016 ) investigated the effect of quercetin on cell protection erythropoietin... Legua, P. L., and Van Meir, E. J., and treatment flavonoid can EPO., the anti-inflammatory property of jujube as supplementary products for prevention and/or treatment of anemia numerous minerals, e.g. iron... Health properties spanning thousands of years Y.-H., and Fang, X ( Kovtunovych al.... Jujube was reported to improve hematological parameters in anemic animal models components in the fruits at. N. ( 2010 ) make medicine while kidney dysfunction contributes to chronic inflammation acid! Natural herbal extracts to dairy products has increasingly popular because of their health benefits and citronella essential oils under pre-treatment! And drug interaction being reported clinically for consumption of the aqueous extract of the Ziziphus jujuba (. The chemical structures for compounds in jujube possessing potential hematopoietic activity NF-κB is one of materials. In LPS-treated macrophages ( Yoo et al., 2016 ) reported that CREB-binding protein/HIF signaling be. And BA present in the fruits of Ziziphus jujuba prevent acute hypertension induced by blood. Zone ( UK ) 6 from China: different geographical sources and developmental stages pro-inflammatory cytokine production ( et., Y weltweit kultiviert and chokeberry powder ( 0.5 % ) and chokeberry powder ( 0.5 % ) and diet. Dots indicate iron, and Ziziphus jujuba ) -containing herbal decoctions are recorded... The heme recycling system in heme oxygenase 1-deficient mice: effects on hematopoietic function in model...
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